Lipofilling in Paris
Regenerative medicine at Henri Mondor Hospital
Lipofilling in Paris
Regenerative medicine, Professor Hersant
For a long time, lipofilling was considered as a volumising treatment, but the discovery of its trophic character (2000) has made lipofilling the most widely used regenerative medicine treatment.
Recent studies have shown that the stromal-vascular fraction of adipose tissue represents a reservoir of precursor cells with pro-angiogenic potential comparable to that of stem cells derived from bone marrow. It has also been shown that mesenchymal stem cells (MSCs) are also present in adipose tissue. Adipose tissue therefore represents a potential new reservoir of pluripotent cells.
Regenerative medicine at Henri Mondor Hospital
Lipofilling in Paris
Autologous adipose tissue transfer is a procedure that has already been used to increase soft tissue volume loss. Grafts of adipose tissue removed by liposuction are re-injected subcutaneously to restore volume to the areas in question. Adipose tissue grafts are used to correct congenital deformities and complex traumatic wounds with loss of soft tissue, after oncological surgery, after the after-effects of radiotherapy and in aesthetic surgery to restructure the face, décolleté, hands, breasts, buttocks, genitals and ankles.
New techniques for harvesting adipose tissue have been developed using cannulas just 0.7 mm in diameter, used to treat delicate areas of the face such as the eyelids and lips.
Lipofilling in Paris
Pr Hersant Plastic, Aesthetic & Reconstructive Surgery
Macrofat
Macrofat fat is characterised by fat lobules with a diameter of 2.4 mm. Macrofat fat is more structural in nature and is easily injected through an 18 or 19 gauge cannula. Macrofat fat is used for structural augmentation of the buttocks and breasts. There is a risk of resorption (30 to 40%), cyto steatonecrosis and oily cysts. A second session may be necessary.
Microfat
Microfat is characterised by lobules of fat with a diameter of 1 mm and is obtained by harvesting fat with cannulas 2 mm in diameter with multiple holes each less than 1 mm in size. The collection microcannula has orifices specifically designed to provide a fat collection consisting of volume-calibrated adipocyte lobules. The deposition microcannula have a diameter calibrated to the size of the cell units obtained with the sampling cannula. (Figure 1)
Microfat is used for trophicity, but also for filling the face, décolleté, hands, genitals and ankles.
Nanofat
Nanofat is characterised by fat lobules of 400 to 600 μm. Nanofat is obtained by taking emulsified microfat and passing it between two 10ml syringes linked together by a female-female Luer-Lok connector. After 3 minutes of continuous transfer (20 to 30 passes), the fat has become an emulsified liquid with a whitish appearance rich in stem cells. The emulsified fat is then filtered through a super-fine filter to obtain the nanofat.
The nanofat can be easily injected using a 27, 30 or 32 G gauge needle. This is a cell seeding designed to improve trophicity.
The nanofats can be centrifuged to remove free fatty acids and create a gel that can be applied in combination with a cream that promotes dermal penetration and can be applied using mesotherapy techniques after laser resurfacing or a facelift. A combination of all three types of fat graft is used in facial aesthetic surgery or facial fat grafting.
Nanofat is used to improve cheek wrinkles, dark circles, lip barring and vulvovaginal dryness.
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